I had never used Adsense for domains, I thought the page had looked ugly and they did not allow you to just change the name servers you had to play around with A records. They changed their system and allow you to switch to their servers which are googleghs.com
Their pages are certainly not as vibrant as some other competitors but they have improved imo. So I tried a few domains and it has been decent.
One frustrating thing is that sometime you have the nameservers changed, but you still have to click verify in your adsense interface, and the name can come back unverified. I had a few geonews.org related domains that were the right nameserver but took three days for the verification to go through.
All in all the first month has been a good experience with Adsense for domains.
If you use them please post your experience.